01 · Focus & adjudication
The honest-state engine
Projects the organism's true epistemic state and ranks where it is weakest — what fails first. Holds the veto that refuses to let the system game its own objective.
What it does
Proven in eleven
dimensions.
ARACHNE v30.5 binds five subsystems into one organism. What follows is what each does, and that it is proven — never how it is built. The mechanism is described. The engine stays private.
Mechanism · proven
/
Efficacy · ignorance
Efficacy resolves with: measured field deployments — 0 to date. Mechanism and efficacy are separate axes and never share a badge.
Five subsystems, one organism
The bound whole.
02 · Evidence sufficiency
PRESCIENT
Returns the minimal, cost-ranked set of evidence that would move a conclusion to a target verdict — or reports that the verdict is structurally unreachable. It speaks to sufficiency, never to outcome.
03 · Domain capabilities
The portable bundle
Twelve additive capability layers — privacy-preserving joint compute, tamper-evident sealed records, signed cross-party quorum, and domain organs for regulated pipelines. Each carries its own test suite.
04 · Biological assessment
The candidate stack
Assesses drug candidates across eleven biological axes, scoring each from named public data sources. A strong dimension cannot mask a weak one; small samples cannot manufacture certainty.
05 · Preventive early-detect
The critical-slowing layer
Watches measured longitudinal signals for the early warning of a coming shift. Detection only, veto-only, fail-open: if it cannot load, the core is never degraded. Its field efficacy is labeled ignorance, by design.
·
Additive by construction
Every subsystem binds over a byte-stable core. Nothing downstream is mutated; every layer is fully reversible. We bind. We never break.
The eleven dimensions
Eleven biological axes.
Each one sourced.
Provenance is not a name-drop. Each axis is scored from named, public, checkable data. The sources are citable; the scoring is not disclosed.
B1
Target engagementChEMBL · BindingDB · Guide to Pharmacology
B2
Structure & mechanismPDBe / RCSB · PubChem
B3
Pathway & networkOpen Targets · Reactome · STRING
B4
Cellular phenotypeDepMap · LINCS L1000 · EBI Expression Atlas
B5
Tissue & organGTEx · Human Protein Atlas
B6
Systems PK/PDEBI BioModels · ClinicalTrials.gov
B7
Safety & toxicityopenFDA FAERS · DILIrank · EPA ToxCast/Tox21 · SIDER
B8
ImmunologicalIEDB
B9
Genomic stratificationGWAS Catalog · ClinVar · PharmGKB · gnomAD
B10
Developability & CMCSAbDab / Thera-SAbDab
B11
Cross-scale fidelityEurope PMC · concordance across all axes above
B11 is the meta-dimension: it proves the other ten agree across scales. Belief that does not propagate consistently is not counted as knowledge.
How it reasons
Five rungs. No "false."
Every conclusion sits on an explicit epistemic ladder. There is no rung for a fabricated negative — the system climbs from ignorance toward certainty only as evidence earns it.
IGNORANCE→
BELIEF→
KNOWLEDGE→
TRUTH→
CERTAINTY
What it doesn't
Everything else is
labeled ignorance.
The firewall is the invention. Every capability sits in one of three honest states, drawn in the open — proven, unclaimed, or building toward. Naming the state is the discipline.
Unclaimed — a gap we name
- Field efficacy is unclaimed. Mechanism is proven by test; efficacy is ignorance by design. Zero deployments are counted as zero.
- One figure, one scope. Where a result is measured, it is stated with the domain it was measured in — never generalized past it.
Building toward — designed for, not yet arrived
- Post-quantum capability and stress resistance. The engine is architected toward post-quantum operation and adversarial stress resistance — a differential built into the design, not yet a claim of arrival. We say building toward, and we mean it precisely.
- 21 CFR Part 11 e-signature. The e-signature posture is designed and tracked toward Part 11. Certification is earned through validation, not declared — so we claim the direction, not the badge.